2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-122385
    Dabequin phosphate
    		Inhibitor
    Dabequin phosphate is an antimalarial agent, that exhibits inhibitory activity against Plasmodium falciparum.
    Dabequin phosphate
  • HY-149938
    Antimalarial agent 25
    		Inhibitor
    Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo.
    Antimalarial agent 25
  • HY-N7082S
    D-Arabinopyranose-13C5
    		Inhibitor
    D-Arabinopyranos-13C5 is 13C labeled D-Arabinopyranos (HY-N7082). D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082).
    D-Arabinopyranose-<sup>13</sup>C<sub>5</sub>
  • HY-W738270
    Veratraldehyde-13C
    Veratraldehyde-13C (3,4-Dimethoxy[7-13C]-benzaldehyde) is the 13C-labeled Veratraldehyde (HY-N1096). Veratraldehyde is an orally active aromatic compound and antibacterial agent. Veratraldehyde can be isolated from essential oils of plants such as peppermint and ginger. Veratraldehyde targets the PilY1 protein. Veratraldehyde has antibacterial activity against Pseudomonas aeruginosa. Veratraldehyde has a repellent effect against mosquitoes and ticks. Veratraldehyde can be used as a flavoring agent.
    Veratraldehyde-<sup>13</sup>C
  • HY-P1957
    Dihydrocyclosporin A
    		Inhibitor
    Dihydrocyclosporin A is a derivative of Cyclosporine A (HY-B0579). Dihydrocyclosporin A significantly inhibites promastigotes and intracellular amastigotes. Dihydrocyclosporin A is highly cytotoxic.
    Dihydrocyclosporin A
  • HY-Y0121R
    Ethyl cinnamate (Standard)
    		Inhibitor
    Ethyl cinnamate (Standard) is the analytical standard of Ethyl cinnamate. This product is intended for research and analytical applications. Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta.
    Ethyl cinnamate (Standard)
  • HY-114969
    Clioxanide
    Clioxanide is a potential anti-liver fluke (Fasciola hepatica) agent. The results showed that Clioxanide showed no efficacy against 4-week-old or 19-week-old flukes at doses of 135 mg/kg or 200 mg/kg. In contrast, hexachloroethane was very effective against older flukes, reaching 100% efficacy at lower doses. The study pointed out that laboratory mice may not be suitable for screening potential compounds against liver fluke infections in ruminants such as cattle and sheep. In addition, no obvious toxic reactions were observed in mice with Clioxanide.
    Clioxanide
  • HY-144297
    HDAC1-IN-3
    HDAC1-IN-3 is a potent Pf HDAC1 inhibitor. HDAC1-IN-3 shows antimalarial activity in wild-type and multidrug-resistant parasite strains. HDAC1-IN-3 shows a significant in vivo killing effect against all life cycles of parasites.
    HDAC1-IN-3
  • HY-101000
    Clazuril
    		Inhibitor
    Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle.
    Clazuril
  • HY-155549
    Antileishmanial agent-20
    		Inhibitor
    Antileishmanial agent-20 is selective towards Leishmania parasite. Antileishmanial agent-20 has IC50 value of 2.8 μM and 0.2 μM for L. infantum and L. braziliensis, respectively. Antileishmanial agent-20 can be used for parasites research.
    Antileishmanial agent-20
  • HY-121003
    Aspyrone
    Aspyrone is a polyketide fungal metabolite that has been found in Aspergillus and has diverse biological activities. It is active against a panel of 13 fungi when used at a concentration of 20 μg/mL and a panel of 21 bacteria in a disc assay when used at a concentration of 100 μg per disc.1 Aspyrone (10-1,000 mg/L) is nematocidal against P. penetrans.
    Aspyrone
  • HY-141621
    ACT-606559
    		Inhibitor
    ACT-606559, a new chemical entity with antimalarial activity, is a metabolite of ACT451840. ACT-606559 can be used for the research of malarial.
    ACT-606559
  • HY-162833
    Antileishmanial agent-30
    		Inhibitor
    Antileishmanial agent-30 (compound 17k) is a potent inhibitor of leishmania, with the IC50, CC50, and SI of 0.2 μM, >100 μM and >500 for L. donovani.
    Antileishmanial agent-30
  • HY-N11031
    Z-Antiepilepsirine
    		Inhibitor
    Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC50 value of 27 µM for W2 strain of Plasmodium falciparum.
    Z-Antiepilepsirine
  • HY-N9475
    Betulonaldehyde
    		Inhibitor
    Betulonaldehyde is a pentacyclic triterpenoid that can be isolated from Diospyros filipendula. Betulonaldehyde has antiplasmodial activity (IC50: 3.36 µg/mL). Betulonaldehyde has cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s: 19.23 and 17.09 µg/mL, respectively). Betulonaldehyde inhibits Phorbol 12-myristate 13-acetate (HY-18739) induced inflammation in mice.
    Betulonaldehyde
  • HY-N3620
    Epiquinamine
    		Inhibitor
    Epiquinamine, an alkaloid, has amoebicidal activity (IC50: 12.9 μg/mL).
    Epiquinamine
  • HY-N7634
    Tectol
    		Inhibitor 99.72%
    Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM.
    Tectol
  • HY-12519G
    Oltipraz (GMP)
    		Inhibitor
    Oltipraz (GMP) is Oltipraz (HY-12519) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Oltipraz has an inhibitory effect on HIF-1α activation. Oltipraz is a potent Nrf2 activator.
    Oltipraz (GMP)
  • HY-N15561
    Batzelladine F
    		Inhibitor
    Batzelladine F is a potent Plasmodium falciparum inhibitor (IC503D7= 0.13 μM). Batzelladine F shows moderate cytotoxicity to HepG2 cells (CC50=10.6 μM) with antimalarial properties. Batzelladine F is promising for research of antimalarial agents.
    Batzelladine F
  • HY-N0152R
    Myricitrin (Standard)
    		Inhibitor
    Myricitrin (Standard) is the analytical standard of Myricitrin. This product is intended for research and analytical applications. Myricitrin, a naturally occurring flavonoid, is an orally active nitric oxide (NO) and PKC inhibitor. Myricitrin has central nervous system activity, including anxiolytic-like action. Myricitrin possesses antioxidant, anti-inflammatory, antifibrotic and anti-malarial effects.
    Myricitrin (Standard)
Parasite Isoform Comparison

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